Računalna analiza modela metabolizma glavnih nutrijenata

master's thesis

• Title (english): Computer analysis of main nutrient metabolism models
• Author: Sara Nadoveza
• Mentor: Ana Jurinjak Tušek (mentor)
• Committee member: Jasenka Gajdoš Kljusurić (predsjednik povjerenstva)
• Committee member: Maja Benković (član povjerenstva)
• Committee member: Ivana Rumora Samarin (član povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Process Engineering); (Laboratory for Measurement, Regulation and Automatisation); Zagreb
• Defense date and country: 2023-05-31, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

U ovom radu provedena je simulacija modela metabolizma glavnih nutrijenata pomoću softverskog alata CellDesigner. Napravljena su četiri jelovnika za četiri dana, namijenjena za dijabetičare, iz kojih su izračunate početne koncentracije ugljikohidrata, masti i proteina. Na temelju početnih koncentracija glavnih nutrijenata uspješno je provedena simulacija modela metabolizma. Rezultati ukazuju na sličan odgovor nutrijenata za sva četiri dana jer se radi o reguliranim jelovnicima čija je primarna uloga regulacija glukoze u krvi. Također je provedena analiza lokalne osjetljivosti parametara gdje je glavni cilj uočiti kako promjene u vrijednosti parametara utječu na izlazne varijable modela. Rezultati su pokazali kako promjena vrijednosti parametara k5, K5, k9 te K9 ima najveći utjecaj na acetil-CoA.

Abstract (english)

In this work, a simulation of the metabolism model of the main nutrients was carried out using the CellDesigner software tool. Four menus for four days were created, intended for diabetics, from which the initial concentrations of carbohydrates, fats and proteins were calculated. Based on the initial concentrations of the main nutrients, the simulation of the metabolism model was successfully carried out. The results indicate a similar response of nutrients for all four days, as these are regulated menus whose primary role is blood glucose regulation. An analysis of the local sensitivity of the parameters was also performed, where the main goal is to observe how changes in the parameter values affect the output variables of the model. The results showed that the change in the value of parameters k5, K5, k9 and K9 has the greatest impact on acetyl-CoA.

• Keywords: metabolizam glavnih nutrijenata; sistemska biologija; računalno modeliranje; CellDesigner; analiza lokalne parametarske osjetljivosti
• Keywords (english): metabolism of main nutrients; system biology; computer modeling; CellDesigner; local parametric sensitivity analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:259755
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-05-15 10:55:20