Priprava disupstituiranog ferocenskog alkohola i alaninola

undergraduate thesis

• Title (english): Synthesis of disubstituted ferrocene alcohol and alaninol
• Author: Katarina Milković
• Mentor: Monika Kovačević (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2024-06-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Tvorba malih molekula koje sadržavaju ferocen, a mogu se upotrijebiti kao prekursori za tvorbu većih, kompleksnih i potencijalno biološki aktivnih molekula predstavlja iznimno zanimljivo područje bioorganometalne kemije. Takvi spojevi su i ferocenski alkoholi koji se mogu upotrijebiti za sintezu posebne vrste peptidomimetika- depsipetida. U ovom radu prikazana je sinteza ferocenskog alkohola COOMe-Fn-CH₂OH (3) koji se dobiva iz ferocenske ester-kiseline selektivnom redukcijom karboksilne skupine u prisutnosti LiAlH₄. Osim ferocenskog alkohola, za potrebe priprave depsipeptida, pripravljen je alaninol-Boc-Ala-CH₂OH (7). Tehnikama infracrvene spektroskopije te spektroskopije nuklearne magnetske rezonancije, provedena je strukturna analiza pripravljenih alkohola.

Abstract (english)

The formation of small ferrocene-containing molecules that can be used as precursors for the formation of larger, more complex and potentially biologically active molecules is an extremely interesting area of bioorganometallic chemistry. Such compounds include ferrocene alcohols, which can be used for the synthesis of a special type of peptidomimetics - depsipe tides. In this paper, the synthesis of the ferrocene alcohol COOMe-Fn-CH₂OH (3) is presented, which is obtained from ferrocene ester acid by selective reduction of the carboxylic group in the presence of LiAlH₄. In addition to ferrocene alcohol, alaninol- Boc-Ala-CH₂OH (7) was also prepared as potential precursor for depsipeptide synthesis. A spectroscopic analysis of the alcohols produced was carried out using spectroscopic techniques, infrared spectroscopyand nuclear magnetic resonance.

• Keywords: ferocen; disupstituirani alkoholi; priprava alkohola; primjena alkohola; alaninol
• Keywords (english): ferrocene; disubstituted alcohols; synthesis of alcohols; application of alcohols; alaninol
• Language: croatian
• URN:NBN: urn:nbn:hr:159:358777
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-11-08 10:28:55