Utjecaj polifenolnog ekstrakta maslinovog ulja na antioksidacijski status tijekom regeneracije jetre u miša

doctoral thesis

• Title (english): Effect of olive oil polyphenolic extract on antioxidant status during liver regeneration in mice
• Author: Jelena Marinić; MBZ: 270274
• Mentor: Čedomila Milin (mentor); MBZ: 70123
• Committee member: Vladimir Mrša (predsjednik povjerenstva); MBZ: 39525
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; Zagreb
• Defense date and country: 2010-12-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Food Technology
• Universal decimal classification (UDC): 665 - Oils. Fats. Waxes. Adhesives. Gums. Resins

Abstract

Promatrani su učinci polifenola iz maslinovog ulja na obrazac ekspresije gena induciranih oksidacijskim stresom te prateći odgovor antioksidanasa i citokina tijekom regeneracije jetre nakon djelomične hepatektomije u miša. Tretman PFE uvećao je razinu antioksidacijske obrane, bit koje čini indukcija ekspresije Nrf2, NF-κB i gena odnosnih transkripcijskih putova, te je potaknuo promjene u intezitetu odgovora i međusobnom odnosu enzimskih i ne enzimskih antioksidanasa te citokina, s konačnim ishodom u poticanju regenerativnog odgovora hepatocita.

Abstract (english)

The effect of the olive oil polyphenols (PFE) on the expression pattern of genes induced by oxidative stress, as well as on the related changes in the antioxidant and cytokine response during the liver regeneration following one third partial hepatectomy was studied in mice. PFE treatment boosted cellular antioxidant defense, underlined by induced expression of NF-κB, Nrf2 and genes encoded by these transcriptional factors, and induced changes in the enzyme and non enzyme antioxidant and cytokines response dynamics, with implication of these events in enhancement of hepatocyte's regenerative response.

• Keywords: Antioksidacijski enzimi; Citokini; Glutation; Maslinovo ulje; polifenoli; Regeneracija jetre; djelomična hepatektomija; Transkripcijski čimbenici; Nrf2; NF-κB
• Keywords (english): Antioxidant enzymes; Cytokines; Glutathione; Olive oil; polyphenols; Liver regeneration; partial hepatectomy; Transcriptional factors; Nrf2; NF-κB
• Language: croatian
• URN:NBN: urn:nbn:hr:159:259568
• Promotion: 2011-07-03
• Study programme: Title: Postgraduate PhD Study in Nutrition; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biotehničkih znanosti, polje nutricionizam (doktor/doktorica znanosti, područje biotehničkih znanosti, polje nutricionizam)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2018-05-15 10:30:22