Respiratory tract represents a direct barrier between organism and environment, therefore constantly exposed to the numerous airborne pathogens and contaminants. Mucosal respiratory airway compartment employs different innate and adaptive immune mechanisms to recognize, neutralize and induce appropriate immune response against invading pathogen. Chemokines are heterogeneous small oligopeptide molecules involved in the chemotaxis of different cells expressing specific chemokine receptors. They are involved in the migration of leukocyte to the pathogen entrance, therefore necessary for an efficient immune reaction development. Besides their structural systematization, chemokines could be functionally grouped in-line with a specific type of immune response involvement. MIG (CXCL9) and IP-10 (CXCL10) chemokines contribute to activation and differentiation of type 1 T cells. Both chemokines are responsible for the chemotaxis of CXCR3-expressing type 1 cells capable to produce IFN-ỵ, which in turn could augment their levels in different viral infections. TARC (CCL17) and MDC (CCL22) chemokines contribute to development of type 2 immune response and higher levels could be found in allergic diseases. They regulate type 2 cell migration via specific CCR4 and their production is positively regulated by the IL-4. In this study, we have detected higher IP-10 and TARC levels in sera of RSV-infected infants. MIG and MCD levels were comparable with healthy infant levels. Increased IP-10 and TARC levels indicate that mixed type of adaptive immune response was acquired during acute RSV-infection which could contribute to immune related pathology observed in diseased infants.