New types of heteroannularly substituted ferrocene peptides

diplomski rad

• Autor: Josipa Bilić
• Mentor: Senka Djaković (mentor)
• Ustanova koja je dodijelila akademski / stručni stupanj: Sveučilište u Zagrebu; Prehrambeno-biotehnološki fakultet; (Zavod za kemiju i biokemiju); (Laboratorij za organsku kemiju); Zagreb
• Datum i država obrane: 2012-07-02, Hrvatska
• Znanstveno / umjetničko područje, polje i grana: BIOTEHNIČKE ZNANOSTI; Biotehnologija

Sažetak

Among artificial peptide building blocks the 1,1'-disubstituted ferrocene scaffold has attracted particular interest because of its unique properties and potential usage in biomedical, nano- and material sciences. Herein we report the synthesis and characterization of unsymmetrical disubstituted ferrocene peptides type I (NOH(CH3)C-Fn-CO-AA-OCH3) and II (NOH(CH3)C-Fn-NH-AA-Boc) with oxime subunit on 1’-cyclopentadienyl ring as potential hydrogen donor/acceptor of hydrogen bond. Prepared bioconjugates I and II were characterized by FTIR, NMR and CD spectroscopy. Conformational analysis of prepared unsymmetrically substituted ferrocene compounds type I and II has shown presence of week to medium intramolecular hydrogen bonds. Positive Cotton effects have been associated with P-helical ferrocene units while negative Cotton effects are considered to be indicative of M-helical ferrocene chromophores which suggest that in this case compounds I form predominantly P-helical conformations while compounds II form M-helical conformations.

• Ključne riječi: ferrocene; peptide; oxime; IHB; synthesis; conformational analysis; spectroscopy
• Jezik: engleski
• URN:NBN: urn:nbn:hr:159:891326
• Studijski program: Naziv: Molekularna biotehnologija; Vrsta studija: sveučilišni; Stupanj studija: diplomski; Akademski / stručni naziv: magistar/magistra inženjer/inženjerka molekularne biotehnologije (mag. ing. biotechn.)
• Vrsta resursa: Tekst
• Način izrade datoteke: Izvorno digitalna
• Prava pristupa: Pristup korisnicima matične ustanove
• Datum i vrijeme pohrane: 2017-05-09 09:22:48